Endogenously produced H2O2 is intimately involved in iron metabolism in Streptococcus pneumoniae
ABSTRACT In the presence of molecular oxygen, the human pathogen Streptococcus pneumoniae produces and secretes large amounts of hydrogen peroxide (H2O2), which can readily interact with free and heme-bound iron.Here, we investigated the role of the endogenously produced H2O2 in iron acquisition.The data revealed that S.pneumoniae uses H2O2 to libe